Which drug is a selective serotonin and norepinephrine reuptake inhibitor (SNRI)?

• A. Duloxetine
• B. Venlafaxine
• C. Fluoxetine
• D. Paroxetine

Answer: (B)

The drug that is classified as a selective serotonin and norepinephrine reuptake inhibitor (SNRI) is Duloxetine. SNRIs work by increasing the levels of both serotonin and norepinephrine in the brain by inhibiting their reuptake into the presynaptic neuron.

Duloxetine is well known for its efficacy in treating major depressive disorder, generalized anxiety disorder, and certain types of chronic pain. Its dual action on both serotonin and norepinephrine receptors is what differentiates it from selective serotonin reuptake inhibitors (SSRIs) like Fluoxetine and Paroxetine, which primarily target serotonin reuptake.

In contrast, Venlafaxine is also an SNRI, especially at higher doses, where it effectively inhibits both serotonin and norepinephrine reuptake, making it another correct example of this drug category. While Fluoxetine and Paroxetine are firmly categorized as SSRIs, they do not exhibit the dual action characteristic of SNRIs.

Thus, Duloxetine stands out as a highly effective SNRI in various therapeutic contexts, underscoring its role in pharmacology.