What is the antidote used for digoxin toxicity?

• A. Leucovorin
• B. Digiband
• C. Flumazenil
• D. Naloxone

Answer: (B)

The antidote used for digoxin toxicity is Digibind, which is a specific antidote designed to counteract the effects of digoxin. Digoxin is a cardiac glycoside commonly used to treat heart conditions like atrial fibrillation and heart failure, but it can lead to toxicity, particularly in cases of renal impairment or when used in conjunction with other medications that affect renal clearance.

Digibind works by binding to digoxin molecules in the bloodstream, forming a complex that can be excreted by the kidneys, thus reducing the active concentration of digoxin in the body. This helps alleviate symptoms associated with toxicity, such as nausea, vomiting, conduction disturbances, and other cardiac effects.

The other options listed do not serve as antidotes for digoxin toxicity. Leucovorin is primarily used to counteract the effects of folate antagonists, flumazenil is an antagonist for benzodiazepines, and naloxone is an opioid antagonist used in cases of opioid overdose. None of these have the capacity to bind to or neutralize digoxin.