Cephalosporins should not be mixed with which solution due to precipitation risks?

• A. Saline
• B. Calcium solutions
• C. Glucose solutions
• D. Normal saline

Answer: (B)

Cephalosporins should not be mixed with calcium solutions due to the risk of precipitation. This concern arises because certain cephalosporins can react with calcium, leading to the formation of insoluble complexes that can precipitate. Such precipitation can block blood vessels or cause other complications if administered intravenously, making it crucial to avoid co-administration or mixing of cephalosporins with calcium-containing solutions.

This particular interaction is important to understand not just in terms of pharmacology but also in the overall safety and efficacy of drug administration. Avoiding this combination helps to prevent adverse effects and ensures that the antibiotics maintain their intended pharmacological activity.